Longevity Shaker
€1,58 / Per Dag 🧬 Met NAD+ Voorloper NR
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Understanding The 12 Hallmarks of Aging
The Scientific Framework Behind The Longevity Store®
These are considered the primary reasons for cellular damage as we age:
• Genomic instability: Accumulation of genetic damage throughout life;
• Telomere attrition: Progressive shortening of telomeres, the protective ends of chromosomes;
• Epigenetic alterations: Changes in gene expression patterns without changes to DNA sequence;
• Loss of proteostasis: Decline in the quality control of proteins within the cell.
These are protective responses to the primary reasons for cellular damage that become harmful when chronic or exacerbated:
- Deregulated nutrient sensing: Changes in the way cells detect and process nutrients;
- Mitochondrial dysfunction: Decreased efficiency of the cell's energy-producing organelles;
- Cellular senescence: Cells that stop dividing but remain metabolically active.
These hallmarks represent the consequences of the primary and antagonistic hallmarks, manifesting as the visible and functional signs of aging:
- Stem cell exhaustion: The gradual depletion and reduced function of stem cells, leading to decreased tissue repair and regeneration capacity;
- Altered intercellular communication: Changes in how cells interact and signal each other, affecting overall tissue and organ function.
These represent more recently identified aspects of aging, expanding our understanding of the complex aging process:
- Chronic inflammation (inflammaging): Persistent low-grade inflammation throughout the body;
- Dysbiosis: Changes in the microbial composition of the gut and other areas.
- Altered mechanical properties: Changes in the physical properties of cells and tissues.
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Your Questions, Answered
Frequently Asked Questions
NMN should be stored in a cool, dry place, away from direct sunlight and heat. Keep it out of reach of children. The stability of Uthever NMN has been tested and confirmed in various studies.
NMN is primarily available in powder form, and accurate measurement is essential.
Measurement Options:
- Precision Scale: For milligram accuracy, use a precision scale available for around 10-15 euros on Amazon.
- Scoop: A scoop holds 1.25 ml, which equates to approximately 600-700 mg of NMN powder.
Uthever® NMN is highly stable with a shelf life of approximately 2 years in a closed bag. The exact shelf life can be found on the back of the stand-up pouch. For more details, please refer to the product page.
NMN - Uthever® is proudly made in the Netherlands, adhering to the highest standards of quality and safety. Our manufacturing process follows strict guidelines to ensure the purity and potency of each ingredient. The production of NMN involves a complex process, including phosphorylation of nicotinamide riboside, and steps like clarification, concentration, and grinding of the substrate, ensuring a purity level of 99%.
The remaining 1% consists of nicotinamide riboside (NR) and nicotinamide (Nam). NR is the starting material, and Nam is the degradation product, both of which are harmless.